| Expression pattern: |
DN |
| Associated gene: |
PI3K/AKT/mTOR signaling pathway, CCNB1 |
| Associated microRNA: |
- |
| Biological function: |
Suppresses tumor cell proliferation and tumor growth; induces cell cycle arrest/retards cell cycle progression. |
| Molecular mechanism: |
Partly inhibits proliferation by inhibiting PI3K/AKT/mTOR signaling and reducing nuclear CCNB1. |
| Biological pathway or process: |
proliferation (inhibits); cell cycle (inhibits); PI3K/AKT/mTOR (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
hsa_circ_0079929 (CDK13-derived) is down-regulated in HCC tissues and HCC cell lines. Its overexpression suppresses HCC tumor cell proliferation and tumorigenesis, and retards cell cycle progression, partly by inhibiting the PI3K/AKT/mTOR pathway and reducing nuclear CCNB1. |
| Confidence score: |
0.6643 |