circRNA basic information
circBase ID: -
Name: hsa_circ_FAT1
Synonym: circFAT1 / chr4:187627717-187630999
Host Gene: FAT1
Genomic location(hg19): chr4:187627717-187630999:.
Genomic location(hg38): chr4:186706563-186709845:.
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

DLD-1; DKO-1; DKs-8; HCT116; HKe3
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: KRAS
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation
Clinical significance:

-
Description:

circFAT1 is consistently reduced in KRAS-mutant colon/colorectal cancer cell lines compared with KRAS WT counterparts and is detectable in exosomes, where it also shows lower abundance in mutant-derived exosomes in at least one comparison.
Confidence score:

0.4773
Other information
Title:

Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes.

Journal: Scientific reports
Published: 2016
PubMed ID: 27892494
Study type:

biological research
Data availability: -
Code availability: -