circRNA basic information
circBase ID: -
Name: hsa_circ_WHSC1
Synonym: circWHSC1
Host Gene: WHSC1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004996
MONDO name: childhood acute myeloid leukemia
Disease details: pediatric acute myeloid leukemia
Disease DO ID:
 0070323
Disease MeSH ID:
 -
Disease NCIt ID:
 C9160
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

diagnosis pediatric AMLs
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: -
Biological function: Associated with patients' event-free survival; higher transcription was associated with increased activity of E2F and MYC target genes, G2M checkpoint genes, protein secretion genes, and mTORC1 signaling.
Molecular mechanism: Predicted peptide-coding potential via IRESs, open reading frames, and a translation initiation site; associated with cell-cycle and mTORC1 pathway activity.
Biological pathway or process:

cell cycle (promotes); PI3K/AKT/mTOR (promotes); other pathway/process (promotes)
Detected method:
S
Validation methods:

RNA-seq; Survival Analysis; Bioinformatics Analysis
Clinical significance:

circWHSC1 was associated with patients' EFS in pediatric AML.
Description:

circWHSC1, derived from WHSC1 exons 2 to 7, was identified as an EFS-associated prognostic circRNA in pediatric AML. Higher transcription was linked to cell-cycle dysregulation and mTORC1-related activity, and the circRNA was predicted to have peptide-coding potential.
Confidence score:

0.348
Other information
Title:

circRNAs as prognostic markers in pediatric acute myeloid leukemia.

Journal: Cancer letters
Published: 2024
PubMed ID: 38621457
Study type:

bioinformatics study; clinical study
Data availability: HRA000789; Supplementary Table 3A; TransCirc database
Code availability: -