circRNA basic information
circBase ID: -
Name: hsa_circ_AKNAD1
Synonym: CircRNA000102
Host Gene: AKNAD1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0005083
MONDO name: psoriasis
Disease details: plaque psoriasis
Disease DO ID:
8893
Disease MeSH ID:
D011565
Disease NCIt ID:
C3346
Disease ICD11 ID:
63698555
Disease OMIM ID:
-
Species: Human
Species details: Homo sapiens
Tissue specimen:

whole blood

Cell lines:

-

In vivo animal model:

-

circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Associated with psoriasis occurrence and progression; may predict disease and was related to treatment category, with higher expression in patients receiving NB-UVB; proposed involvement in immune cell balance and inflammation.
Molecular mechanism: Mechanism in psoriasis was not directly validated; authors generally propose that examined circRNAs may sponge microRNAs and modulate genes including cytokine expression and immune/inflammatory components.
Biological pathway or process:

immune regulation (other); inflammation (other)

Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis

Clinical significance:

circRNA000102 had diagnostic performance for discriminating psoriasis from controls and was an independent factor for predicting psoriasis.

Description:

circRNA000102 (AKNAD1) was significantly down-regulated in blood from plaque psoriasis patients and showed diagnostic value for psoriasis. Unlike circRNA0045272 and circRNA0084764, no specific miRNA correlation was reported for circRNA000102 in this study, so its mechanistic role remains less defined.

Confidence score:

0.4187

Other information
Title:

Estimate of circRNAs and microRNAs synergies on clinical advance of psoriasis.

Journal: Journal of immunoassay & immunochemistry
Published: 2025
PubMed ID: 39997071
Study type:

clinical study

Data availability: The datasets generated during and/or analyzed during the current study are not publicly available but are available from the corresponding author on reasonable request.
Code availability: -