| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential protective biomarker and therapeutic target; downregulation may be associated with reduced HK-2 cell viability, increased apoptosis, oxidative stress, and sepsis-induced AKI pathogenesis. |
| Molecular mechanism: |
Exosomal circRNA expression dysregulation associated with apoptosis and oxidative stress regulation; detailed molecular mechanism was not functionally validated in this study. |
| Biological pathway or process: |
apoptosis (inhibits); proliferation (promotes); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation |
| Clinical significance: |
Potential biomarker and therapeutic target for sepsis-induced AKI. |
| Description: |
circ-Ttc3 was significantly downregulated in plasma exosomes from patients with sepsis-induced AKI and also reduced in HK-2 cells treated with AKI-derived exosomes. The study suggests that circ-Ttc3 may have a protective role related to apoptosis and oxidative stress regulation and may serve as a candidate biomarker or therapeutic target. |
| Confidence score: |
0.2995 |