| Expression pattern: |
UP |
| Associated gene: |
KRAS |
| Associated microRNA: |
miR-622 |
| Biological function: |
promotes tumor cell viability, proliferation, invasion, and migration |
| Molecular mechanism: |
acts as an miR-622 sponge to promote KRAS expression at both mRNA and protein levels |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); migration (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
circ_GLG1 could be used as a potential diagnostic biomarker |
| Description: |
circ_GLG1 is up-regulated in colorectal cancer tissues and CRC cell lines and acts as an oncogenic circRNA. It sponges miR-622 to increase KRAS expression (mRNA and protein), thereby promoting CRC cell proliferation, viability, invasion, and migration in vitro. |
| Confidence score: |
0.6829 |