| Expression pattern: |
UP |
| Associated gene: |
HIF1AN, NRF-2, HO-1 |
| Associated microRNA: |
miR-24-3p |
| Biological function: |
Promotes periodontitis progression, inflammation, oxidative stress and apoptosis in PDLCs; inhibits cell viability and osteogenic differentiation. |
| Molecular mechanism: |
circPVT1 acts as a ceRNA by sponging miR-24-3p to regulate HIF1AN and modulates the NRF-2/HO-1 pathway. |
| Biological pathway or process: |
ceRNA regulation (other); inflammation (promotes); apoptosis (promotes); proliferation (inhibits); oxidative phosphorylation (other); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Annexin V/PI Flow Cytometry; ELISA; Western Blot |
| Clinical significance: |
Regulation of circPVT1/miR-24-3p/HIF1AN pathway may serve as a potential therapeutic target for periodontitis. |
| Description: |
circPVT1 is up-regulated in gingival tissues from periodontitis patients and in LPS-treated PDLCs. The study supports that circPVT1 promotes periodontitis progression by sponging miR-24-3p, regulating HIF1AN, and modulating NRF-2/HO-1-related inflammation and oxidative stress responses. |
| Confidence score: |
0.7936 |