| Expression pattern: |
UP |
| Associated gene: |
CEP55 |
| Associated microRNA: |
miR-1244 |
| Biological function: |
promotes proliferation, migration, invasion and glycolysis; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0136666 sponges miR-1244 to increase CEP55 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; EdU Staining; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; Clinical Sample Validation; Bioinformatics Analysis; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
High level of circ_0136666 was associated with advanced tumor-node-metastasis (TNM) stage, large tumor size, and increased invasion depth in OS patients. |
| Description: |
circ_0136666 is up-regulated in osteosarcoma and acts as an oncogenic circRNA. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-1244 to increase CEP55 expression, thereby promoting proliferation, migration/invasion, glycolysis, and tumor growth while inhibiting apoptosis. |
| Confidence score: |
0.8174 |