| Expression pattern: |
UP |
| Associated gene: |
FTO, PI3K, AKT, mTOR |
| Associated microRNA: |
- |
| Biological function: |
hsa_circ_0112136 functions as a tumor promoter in gastric cancer; its suppression reduced GC cell viability, migration, invasion and delayed tumor growth in vivo. |
| Molecular mechanism: |
FTO inhibits m6A modification of hsa_circ_0112136, thereby enhancing hsa_circ_0112136 expression; hsa_circ_0112136 promotes GC tumorigenesis by activating the PI3K/AKT/mTOR signaling pathway. |
| Biological pathway or process: |
PI3K/AKT/mTOR (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); m6A modification (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); MeRIP / MeRIP-seq; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
High hsa_circ_0112136 expression was correlated with larger tumor size, advanced TNM stage, poor differentiation, and distant metastasis; it may serve as a novel therapeutic target or biomarker for GC diagnosis and treatment. |
| Description: |
hsa_circ_0112136 is up-regulated in gastric cancer and acts as an oncogenic circRNA. FTO-mediated demethylation decreases m6A modification of hsa_circ_0112136 and increases its expression, thereby promoting GC cell viability, migration, invasion and xenograft tumor growth through activation of the PI3K/AKT/mTOR pathway. |
| Confidence score: |
0.795 |