circRNA basic information
circBase ID: -
Name: hsa_circ_RNF111
Synonym: circ-RNF111
Host Gene: RNF111
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008170
MONDO name: ovarian cancer
Disease details: ovarian cancer
Disease DO ID:
 2394
Disease MeSH ID:
 D010051
Disease NCIt ID:
 C7431
Disease ICD11 ID:
 685124533
Disease OMIM ID:
 167000
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

SKOV-3; IOSE80
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CCND1
Associated microRNA: miR-556-5p
Biological function: promotes proliferation and increases cell viability of SKOV-3 ovarian cancer cells
Molecular mechanism: circ-RNF111 acts as a sponge for miR-556-5p to up-regulate CCND1 expression
Biological pathway or process:

proliferation (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Western Blot
Clinical significance:

Circ-RNF111 may serve as a potential target for ovarian cancer therapy.
Description:

circ-RNF111 is up-regulated in SKOV-3 ovarian cancer cells compared with IOSE80 cells. It promotes SKOV-3 cell proliferation and viability by sponging miR-556-5p and increasing CCND1 expression, suggesting a potential therapeutic target role in ovarian cancer.
Confidence score:

0.5554
Other information
Title:

Circ-RNF111 Promotes Proliferation of Ovarian Cancer Cell SKOV-3 by Targeting the MiR-556-5p/CCND1 Axis.

Journal: Biochemical genetics
Published: 2024
PubMed ID: 38376577
Study type:

biological research
Data availability: The data that support the findings of this study are available from the authors upon reasonable request.
Code availability: -