circRNA basic information
circBase ID: -
Name: hsa_circ_NFIX
Synonym: circNFIX
Host Gene: NFIX
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; paired normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: MMP9
Associated microRNA: has-miR-6794-5p
Biological function: may regulate fatty acid metabolism and MMP9 expression in breast cancer
Molecular mechanism: ceRNA mechanism involving has-miR-6794-5p and regulation of MMP9
Biological pathway or process:

ceRNA regulation (promotes); lipid metabolism (other pathway/process)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

circNFIX is up-regulated in breast cancer tissues and is highlighted in the constructed ceRNA network. It is proposed to act as a ceRNA associated with has-miR-6794-5p and to regulate MMP9 and fatty acid metabolism-related processes in breast cancer.
Confidence score:

0.1768
Other information
Title:

Differential expression profile of mRNAs, lncRNAs, and circRNAs reveals potential molecular mechanism in breast cancer.

Journal: Bioscience reports
Published: 2022
PubMed ID: 35852149
Study type:

combined biological and clinical study
Data availability: The data generated or analyzed to support the current study are included within the article.
Code availability: -