| Expression pattern: |
UP |
| Associated gene: |
SLC7A11 |
| Associated microRNA: |
miR-1261 |
| Biological function: |
Promotes HCC cell proliferation, invasion, tumor growth and metastasis; knockdown promotes ferroptosis. |
| Molecular mechanism: |
ceRNA mechanism: circ0097009 sponges miR-1261 to regulate SLC7A11, affecting ferroptosis (system Xc- and GPX4-related). |
| Biological pathway or process: |
ferroptosis (inhibits); proliferation (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
Circ0097009 may be used as a diagnostic biomarker for HCC and as a potential target for HCC therapy. |
| Description: |
circ0097009 (hsa_circ_0097009), derived from SLC5A8, is up-regulated in HCC tissues and cell lines and promotes malignant phenotypes (proliferation, invasion, tumor growth and metastasis). Mechanistically, it sponges miR-1261 to de-repress SLC7A11, thereby inhibiting ferroptosis (system Xc- and GPX4-related) and facilitating HCC progression. |
| Confidence score: |
0.8442 |