| Expression pattern: |
UP |
| Associated gene: |
mTOR |
| Associated microRNA: |
miR-1271-5p |
| Biological function: |
promotes proliferation, migration, invasion, tumorigenesis, and metastasis in prostate cancer |
| Molecular mechanism: |
Acts as a miRNA sponge/decoy for miR-1271-5p to upregulate mTOR, activating PI3K/Akt signaling. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); PI3K/AKT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; RNA-seq |
| Clinical significance: |
High circMBOAT2 expression was associated with high Gleason score, advanced pathological T stage, and shorter DFS (poor prognosis). |
| Description: |
circMBOAT2 is up-regulated in prostate cancer tissues and cell lines and promotes proliferation, migration, invasion, tumor growth and metastasis. It functions as a ceRNA that sponges miR-1271-5p to de-repress mTOR, activating PI3K/Akt signaling; high circMBOAT2 is associated with shorter DFS. |
| Confidence score: |
0.8837 |