circRNA basic information
circBase ID: -
Name: hsa_circ_AFF2
Synonym: circAFF2
Host Gene: AFF2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005180
MONDO name: Parkinson disease
Disease details: Parkinson’s disease / PD
Disease DO ID:
 14330
Disease MeSH ID:
 D010300
Disease NCIt ID:
 C26845
Disease ICD11 ID:
 296066191
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential biomarker for PD; associated with symptom severity measures (UPDRS-III; MoCA).
Molecular mechanism: Predicted miRNA targeting (in-silico) with circRNA-miRNA correlations; downstream pathway enrichment via miRNAs.
Biological pathway or process:

Hippo/YAP (other); other pathway/process (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis; ROC Analysis
Clinical significance:

Associated with PD and evaluated as part of circRNA biomarkers; circAFF2 correlated with UPDRS-III and MoCA.
Description:

circAFF2 is differentially accumulated (up-regulated) in PD blood in cross-sectional analyses and is one of five high-confidence circRNAs highlighted by the study. It shows significant correlations with motor severity (UPDRS-III) and cognitive score (MoCA) and is evaluated as part of circRNA biomarker efforts.
Confidence score:

0.348
Other information
Title:

Circulating blood circular RNA in Parkinson's Disease; a systematic study.

Journal: medRxiv : the preprint server for health sciences
Published: 2024
PubMed ID: 38343838
Study type:

bioinformatics study
Data availability: PDBP; PPMI
Code availability: -