| Expression pattern: |
UP |
| Associated gene: |
CXCR5 |
| Associated microRNA: |
miR-326 |
| Biological function: |
circ-PGAM1 enhances matrine resistance of NSCLC cells, promotes colony formation/proliferation under matrine treatment, suppresses matrine-induced apoptosis, and is associated with lung cancer progression and poor overall survival. |
| Molecular mechanism: |
circ-PGAM1 mediates matrine resistance in NSCLC cells through regulation of the miR-326/CXCR5 axis. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); drug resistance (promotes); chemoresistance (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Transfection; Colony Formation Assay; TUNEL; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ-PGAM1 expression was associated with poor overall survival in lung cancer patients. |
| Description: |
circ-PGAM1 is up-regulated in NSCLC cell lines and TCGA lung adenocarcinoma tumor samples. Functionally, circ-PGAM1 enhances resistance of NSCLC cells to matrine by promoting colony formation and inhibiting apoptosis under matrine treatment. Mechanistically, the study implicates a circ-PGAM1/miR-326/CXCR5 regulatory axis, and high circ-PGAM1 expression is associated with poor overall survival. |
| Confidence score: |
0.5546 |