circRNA basic information
circBase ID: hsa_circ_0000007
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr1:1735857-1737977:-
Genomic location(hg38): chr1:1804418-1806538:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: Colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancerous tissues; adjacent tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: RB1 gene
Associated microRNA: -
Biological function: Potential biomarker for CRC diagnosis and staging; may regulate RB1-mediated G1-S phase cell cycle control.
Molecular mechanism: Potential regulation of RB1 gene, possibly through a circRNA-miRNA-mRNA axis; associated with transcriptional regulation during the G1-S phase of mitosis.
Biological pathway or process:

cell cycle (other); other pathway/process (other)
Detected method:
M
Validation methods:

Microarray; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential biomarker for CRC diagnosis and staging.
Description:

hsa_circ_0000007 was identified as a key circRNA whose expression decreased with CRC progression. The study suggests it may be associated with RB1-mediated G1-S phase transcriptional regulation and may serve as a biomarker for CRC diagnosis and staging.
Confidence score:

0.348
Other information
Title:

A Preliminary Study of CircRNA Expression Characteristics in the Progression of Colorectal Cancer.

Journal: Biotechnology and applied biochemistry
Published: 2025
PubMed ID: 39957397
Study type:

combined clinical and bioinformatics study
Data availability: The datasets used and analyzed during the current study are available from the corresponding author upon reasonable request.
Code availability: -