| Expression pattern: |
UP |
| Associated gene: |
WNT2 |
| Associated microRNA: |
miR-548b-3p |
| Biological function: |
promotes proliferation, migration and invasion; induces apoptosis when silenced |
| Molecular mechanism: |
miRNA sponge binding miR-548b-3p; negatively correlates with miR-548b-3p; rescue by miR-548b-3p inhibitor |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Cohort Study; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; RNA Pull-Down; Bioinformatics Analysis |
| Clinical significance: |
High hsa_circ_0001944 expression indicated shorter OS and RFS and was an independent prognostic factor in CRC. |
| Description: |
hsa_circ_0001944 is up-regulated in colorectal cancer and high expression predicts worse OS/RFS. Functionally, it promotes CRC cell proliferation, migration and invasion and suppresses apoptosis, at least partly by binding (sponging) miR-548b-3p. |
| Confidence score: |
0.7948 |