| Expression pattern: |
UN |
| Associated gene: |
QKI6, PD-L1, STUB1, OTUB1 |
| Associated microRNA: |
- |
| Biological function: |
Inhibits subcutaneous tumour growth in vivo and increases CD8 infiltration/activation markers; associated with reduced PD-L1 protein in tumours. |
| Molecular mechanism: |
In tumours from mmu_circ_0000860-overexpressing cells, QKI6 and STUB1 proteins are increased while PD-L1 and OTUB1 proteins are reduced, consistent with enhanced PD-L1 ubiquitination/degradation. |
| Biological pathway or process: |
proliferation (inhibits); immune regulation (promotes); ubiquitination (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Western Blot; Transfection; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry) |
| Clinical significance: |
- |
| Description: |
In a mouse syngeneic tumour model using LLC cells, overexpression of mmu_circ_0000860 suppresses tumour growth and increases CD8 staining in tumours. Tumour protein changes (higher QKI6/STUB1 and lower PD-L1/OTUB1) align with reduced immune evasion via PD-L1 downregulation. |
| Confidence score: |
0.5358 |