circRNA basic information
circBase ID: hsa_circ_0003026
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr16:84773914-84779279:+
Genomic location(hg38): chr16:84740308-84745673:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum samples; serum exosomes; cellular extracts
Cell lines:

A549; AT2 cell
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: hsa_circ_0003026 is significantly upregulated in NSCLC serum exosomes and shows promise as a non-invasive diagnostic biomarker; the study suggests potential involvement in disease pathogenesis.
Molecular mechanism: -
Biological pathway or process:

not specified (other)
Detected method:
Q
Validation methods:

Clinical Sample Validation
Clinical significance:

hsa_circ_0003026 shows promise as a non-invasive diagnostic biomarker for NSCLC and may support liquid biopsy-based diagnosis and disease monitoring.
Description:

This study developed and applied a CRISPR/Cas13a-induced self-priming cyclic amplification assay to detect exosomal hsa_circ_0003026. hsa_circ_0003026 was significantly upregulated in serum exosomes from NSCLC patients compared with healthy controls, supporting its potential as a liquid biopsy biomarker for NSCLC diagnosis.
Confidence score:

0.208
Other information
Title:

CRISPR/Cas13a-induced self-priming cyclic amplification enables liquid biopsy of exosomal circular RNA in non-small cell lung cancer.

Journal: The Analyst
Published: 2026
PubMed ID: 41636073
Study type:

combined method development and clinical study
Data availability: Data available within the article or its supplementary information (SI); https://doi.org/10.1039/d5an01345c
Code availability: -