circRNA basic information
circBase ID: hsa_circ_0048234
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr19:1417498-1432689:+
Genomic location(hg38): chr19:1417499-1432690:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: EGFR
Associated microRNA: miR-671-5p
Biological function: may inhibit chemoradiation resistance
Molecular mechanism: Speculative ceRNA/miRNA-binding model: hsa_circ_0048234 contains miR-671-5p binding sites; its downregulation may increase EGFR signaling and promote CRR.
Biological pathway or process:

EGFR (promotes); ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0048234 is discussed as a downregulated circRNA with predicted miR-671-5p binding sites. The authors suggest that its downregulation could increase EGFR signaling and promote chemoradiation resistance, but this is presented as a possibility rather than experimentally validated in this study.
Confidence score:

0.1768
Other information
Title:

Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.

Journal: BioMed research international
Published: 2017
PubMed ID: 28656150
Study type:

biological research; bioinformatics study
Data availability: -
Code availability: -