| Expression pattern: |
UP |
| Associated gene: |
SOX4, AGO2 |
| Associated microRNA: |
miR-507, miR-557, miR-579-3p, miR-1287-5p |
| Biological function: |
Promotes NSCLC cell proliferation and xenograft growth; accelerates cell cycle progression; inhibits apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-507/miR-557/miR-579-3p/miR-1287-5p to up-regulate SOX4. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; In Vivo Animal Model; IF (Immunofluorescence); TUNEL; ROC Analysis; Clinical Sample Validation |
| Clinical significance: |
circ_0089823 level differentiates NSCLC tissues from adjacent non-cancer tissues (AUC 0.9537) and is associated with gender, tumor size, pathological type, TNM stage and smoking history. |
| Description: |
circ_0089823 is up-regulated in NSCLC tissues and cell lines and primarily localizes to the cytoplasm. It promotes NSCLC proliferation and tumor growth while inhibiting apoptosis, mainly by sponging miR-507/miR-557/miR-579-3p/miR-1287-5p to up-regulate SOX4. |
| Confidence score: |
0.8432 |