| Expression pattern: |
UP |
| Associated gene: |
HK2 |
| Associated microRNA: |
miR-874-3p |
| Biological function: |
circ-CCS promotes CRC progression and oxaliplatin resistance by enhancing the IC50 value of oxaliplatin, cell proliferation, migration, invasion and glycolysis metabolism, while inhibiting apoptosis; circ-CCS knockdown suppresses tumor growth and strengthens oxaliplatin sensitivity in vivo. |
| Molecular mechanism: |
circ-CCS acts as a sponge for miR-874-3p and indirectly regulates HK2 expression through the miR-874-3p/HK2 axis, affecting glycolysis metabolism and oxaliplatin resistance. |
| Biological pathway or process: |
ceRNA regulation (other); glycolysis (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); chemoresistance (promotes); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Higher circ-CCS levels were associated with more advanced tumors, lymph node metastases and larger tumor size in CRC patients. |
| Description: |
circ-CCS is up-regulated in colorectal cancer and especially in oxaliplatin-resistant CRC tissues and cells. Functionally, circ-CCS promotes oxaliplatin resistance, proliferation, migration, invasion and glycolysis metabolism while suppressing apoptosis; its knockdown inhibits tumor growth and improves oxaliplatin sensitivity in vivo. Mechanistically, circ-CCS acts through the miR-874-3p/HK2 axis. |
| Confidence score: |
0.786 |