| Expression pattern: |
UP |
| Associated gene: |
YAP1 |
| Associated microRNA: |
miR-1270 |
| Biological function: |
circ_0091579 promoted HCC progression, proliferation, angiogenesis, invasion, migration, tumor growth in vivo, and glutamine metabolism, while inhibiting apoptosis. |
| Molecular mechanism: |
circ_0091579 acts as a miR-1270 sponge to upregulate YAP1 expression, thereby promoting HCC progression and glutamine metabolism. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); angiogenesis (promotes); invasion (promotes); migration (promotes); glutaminolysis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Tube Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); ELISA |
| Clinical significance: |
circ_0091579 might offer novel biomarkers and therapeutic targets for HCC. |
| Description: |
hsa_circ_0091579/circ_0091579 is up-regulated in HCC tissues and cells. It promotes HCC cell proliferation, angiogenesis, invasion, migration, in vivo tumor growth, and glutamine metabolism while suppressing apoptosis. Mechanistically, circ_0091579 sponges miR-1270 to regulate YAP1 expression, suggesting a potential therapeutic target for HCC. |
| Confidence score: |
0.8299 |