circRNA basic information
circBase ID: hsa_circ_0007099
Name: hsa_circ_ABHD2
Synonym: CircABHD2
Host Gene: ABHD2
Genomic location(hg19): chr15:89656955-89659752:+
Genomic location(hg38): chr15:89113724-89116521:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0011962
MONDO name: endometrial cancer
Disease details: endometrial cancer
Disease DO ID:
 1380
Disease MeSH ID:
 -
Disease NCIt ID:
 C27815
Disease ICD11 ID:
 -
Disease OMIM ID:
 608089
Species: Human
Species details: Homo sapiens
Tissue specimen:

EC tissues; normal endometrial tissues
Cell lines:

HEC-1-A; ishikawa; RL95-2; hESCs
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: NAMPT protein, NAD +
Associated microRNA: -
Biological function: CircABHD2 inhibits EC cell proliferation, migration, and invasion, promotes apoptosis, and causes cell cycle arrest.
Molecular mechanism: CircABHD2 inhibits malignant progression of EC by regulating the NAD + /NAMPT metabolic axis and reducing NAMPT protein expression and NAD + levels.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); cell cycle (inhibits); lipid metabolism (other); other pathway/process (inhibits)
Detected method:
Q
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; RNA-seq; FISH / smFISH; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Wound Healing Assay; Western Blot; ROC Analysis; Bioinformatics Analysis
Clinical significance:

CircABHD2 expression was closely related to FIGO stage and differentiation degree, showed favorable diagnostic value with AUC 0.865, and may serve as a promising diagnostic biomarker and potential therapeutic target for EC.
Description:

CircABHD2 (hsa_circ_0007099), derived from ABHD2, is down-regulated in endometrial cancer tissues and cells. It acts as a tumor suppressor by inhibiting proliferation, migration, and invasion, promoting apoptosis, and inducing cell cycle arrest. Mechanistically, circABHD2 reduces NAD + levels and NAMPT protein expression, implicating the NAD + /NAMPT metabolic axis, and it also shows potential diagnostic value for EC.
Confidence score:

0.786
Other information
Title:

CircABHD2 Inhibits Malignant Progression of Endometrial Cancer by Regulating NAD+/NAMPT Metabolism Axis.

Journal: Molecular biotechnology
Published: 2025
PubMed ID: 38951482
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request; Supplementary material available at https://doi.org/10.1007/s12033-024-01226-2
Code availability: -