| Expression pattern: |
UP |
| Associated gene: |
VEGFA |
| Associated microRNA: |
miR-199a |
| Biological function: |
circUBAP2 facilitates CRC progression; circUBAP2 knockdown inhibits CRC cell proliferation, migration, and invasion. |
| Molecular mechanism: |
circUBAP2 acts as a ceRNA by sponging miR-199a to upregulate VEGFA expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
circUBAP2 may be a potential therapeutic biomarker for CRC. |
| Description: |
circUBAP2 is upregulated in colorectal cancer tissues and cell lines. It promotes CRC cell proliferation, migration, and invasion by sponging miR-199a and thereby upregulating VEGFA, suggesting a potential therapeutic biomarker role in CRC. |
| Confidence score: |
0.6521 |