| Expression pattern: |
DN |
| Associated gene: |
2791 potential target mRNAs |
| Associated microRNA: |
hsa-miR-136 |
| Biological function: |
inhibits glioma carcinogenesis; suppresses glioma cell proliferation, migration and invasion; suppresses intracranial tumor growth and prolongs survival in vivo |
| Molecular mechanism: |
ceRNA mechanism through interaction with miRNAs and downstream target mRNAs; predicted modulation of PI3K-Akt, MAPK and Ras signaling pathways |
| Biological pathway or process: |
ceRNA regulation (other); PI3K/AKT (inhibits); MAPK (inhibits); apoptosis (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits); other pathway/process (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; In Vivo Animal Model |
| Clinical significance: |
potential diagnostic and therapeutic biomarker; candidate molecule for therapeutic strategies |
| Description: |
hsa_circ_0001681 is a down-regulated circRNA in glioma and was experimentally validated as a circular transcript derived from RAPGEF5. Its overexpression suppresses glioma cell proliferation, migration, invasion and intracranial tumor growth, likely through a circRNA-miRNA-mRNA ceRNA network affecting PI3K-Akt, MAPK and Ras-related signaling. |
| Confidence score: |
0.6867 |