| Expression pattern: |
UP |
| Associated gene: |
FOXO3, JunB, ITGbeta6, TGF-beta, p-Smad2, Ago2 |
| Associated microRNA: |
miR-141-3p |
| Biological function: |
Promotes periodontal inflammation and periodontitis progression; down-regulates ITGbeta6 expression; suppresses TGF-beta activity; circFOXO3 inhibition alleviates alveolar bone resorption and periodontal inflammation in rats. |
| Molecular mechanism: |
circFOXO3 acts as an miR-141-3p sponge, increases FOXO3, promotes FOXO3-JunB transcriptional repression, inhibits JunB binding to the ITGbeta6 promoter, down-regulates ITGbeta6 transcription, and reduces ITGbeta6-mediated TGF-beta/Smad2 activity. |
| Biological pathway or process: |
inflammation (promotes); TGF-beta/SMAD (inhibits); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
H
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; FISH / smFISH; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; Co-IP; ChIP / ChIP-seq; IF (Immunofluorescence); IHC (Immunohistochemistry); Western Blot; In Vivo Animal Model; H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
Potential therapeutic target for periodontitis; local administration of anti-circFOXO3 small RNAs showed preventive and therapeutic efficacy against periodontal inflammation and alveolar bone resorption in rats. |
| Description: |
circFOXO3 is up-regulated in gingival epithelial tissues from patients with periodontitis and is mainly cytoplasmic. It promotes periodontal inflammation by sponging miR-141-3p, increasing FOXO3, forming a FOXO3-JunB transcriptional repression mechanism, down-regulating ITGbeta6, and inhibiting TGF-beta/Smad2 activity. In a rat ligature-induced periodontitis model, local si-circFOXO3 treatment alleviated inflammation and alveolar bone resorption, suggesting therapeutic potential. |
| Confidence score: |
0.8729 |