| Expression pattern: |
UP |
| Associated gene: |
GDPD5 |
| Associated microRNA: |
miR-874-3p |
| Biological function: |
Promotes BC cell proliferation, viability, clone formation, migration, and invasion. |
| Molecular mechanism: |
circKIF4A acts as a molecular sponge for miR-874-3p, inhibiting miR-874-3p and thereby upregulating GDPD5 expression to promote malignant BC cell behaviors. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Potential therapeutic target in BC. |
| Description: |
circKIF4A is upregulated in human breast cancer cell lines and functions as an oncogenic circRNA. It is predominantly cytoplasmic and promotes proliferation, viability, migration, and invasion by sponging miR-874-3p and increasing GDPD5 expression, suggesting potential therapeutic relevance in BC. |
| Confidence score: |
0.7204 |