| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
valuable diagnostic biomarker to differentiate AML patients from healthy controls; may influence AML prognosis and was associated with lacking complete remission and leukocytosis |
| Molecular mechanism: |
not specified |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Cohort Study; Survival Analysis |
| Clinical significance: |
circ-VIM could distinguish AML patients from healthy controls; high circ-VIM expression was correlated with lacking complete remission and leukocytosis, and showed a non-significant trend toward lower overall survival |
| Description: |
In this clinical biomarker study, circ-VIM was significantly up-regulated in AML patients compared with healthy controls and showed diagnostic value by ROC analysis. High circ-VIM expression was associated with leukocytosis and lack of complete remission, and the authors suggested it may influence AML prognosis despite no statistically significant OS association in this cohort. |
| Confidence score: |
0.4992 |