circRNA basic information
circBase ID: hsa_circ_0002232
Name: hsa_circ_PTEN
Synonym: circ_0002232
Host Gene: PTEN
Genomic location(hg19): chr10:89624210-89693008:+
Genomic location(hg38): chr10:87864453-87933251:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018874
MONDO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Disease DO ID:
 9119
Disease MeSH ID:
 D015470
Disease NCIt ID:
 C3171
Disease ICD11 ID:
 -
Disease OMIM ID:
 601626
Species: Human
Species details: Homo sapiens
Tissue specimen:

BM sample
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: valuable diagnostic biomarker to differentiate AML patients from healthy controls; associated with overall survival in AML patients
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Cohort Study; Survival Analysis
Clinical significance:

circ_0002232 could distinguish AML patients from healthy controls; downregulated circ_0002232 was associated with increased overall survival, while upregulated circ_0002232 patients had worse prognosis
Description:

In this clinical biomarker study, circ_0002232 was significantly down-regulated in AML patients compared with healthy controls and showed diagnostic value by ROC analysis. Lower circ_0002232 expression was associated with better overall survival, indicating that higher circ_0002232 expression was linked to poorer prognosis in this cohort.
Confidence score:

0.4992
Other information
Title:

Evaluation of circ_0002232 and circ-vimentin gene expressions as valuable biomarkers in acute myeloid leukemia patients.

Journal: Molecular biology reports
Published: 2025
PubMed ID: 39776264
Study type:

clinical study
Data availability: Supplementary material available at https:// doi. org/ 10. 1007/ s11033-024-10113-7
Code availability: -