| Expression pattern: |
DN |
| Associated gene: |
beta-catenin, c-Myc |
| Associated microRNA: |
miR-7, miR-383 |
| Biological function: |
Inhibits HCC cell proliferation, migration and invasion; enhances sensitivity to cisplatin (suppresses cisplatin chemoresistance); suppresses tumor growth in vivo. |
| Molecular mechanism: |
Knockdown of circ_0003418 activates the Wnt/beta-catenin signaling pathway (increased beta-catenin and c-Myc); inhibition of Wnt/beta-catenin reverses the cisplatin-sensitivity effect associated with circ_0003418 knockdown. |
| Biological pathway or process: |
Wnt/beta-catenin (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); chemoresistance (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circ_0003418 expression correlated with tumor size, TNM stage and HBsAg level in HCC patients; suggested as a biomarker for diagnosis and prediction for outcome. |
| Description: |
circ_0003418 is down-regulated in HCC tissues and cell lines and acts as a tumor suppressor. Its knockdown promotes proliferation/migration/invasion and increases cisplatin resistance, partly by activating Wnt/beta-catenin signaling (beta-catenin and c-Myc), while Wnt/beta-catenin inhibition reverses these effects. |
| Confidence score: |
0.5414 |