| Expression pattern: |
DN |
| Associated gene: |
CADM3 |
| Associated microRNA: |
miR-346 |
| Biological function: |
circPFKP suppresses gastric cancer progression by inhibiting cell proliferation, migration, invasion, and tumor growth in vivo. |
| Molecular mechanism: |
circPFKP acts as a ceRNA and molecular sponge for miR-346, thereby regulating CADM3 expression through the circPFKP/miR-346/CADM3 axis. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; FISH / smFISH; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Transwell Assay; In Vivo Animal Model; Western Blot |
| Clinical significance: |
circPFKP may provide a novel biomarker and potential therapeutic target for the diagnosis and treatment of gastric cancer. |
| Description: |
circPFKP is down-regulated in gastric cancer tissues and cell lines and acts as a tumor-suppressive circRNA. It inhibits GC cell proliferation, migration, invasion, and xenograft tumor growth by functioning as a ceRNA that sponges miR-346 and up-regulates CADM3, suggesting potential diagnostic or therapeutic value. |
| Confidence score: |
0.7404 |