circRNA basic information
circBase ID: hsa_circ_0075792
Name: -
Synonym: circ_0075792
Host Gene: -
Genomic location(hg19): chr6:18212718-18214012:+
Genomic location(hg38): chr6:18212487-18213781:+
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: HBV-related hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

urine
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Noninvasive urinary biomarker for detecting HBV-related HCC, especially early HCC and surveillance of high-risk patients.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Urinary circ_0075792 was significantly increased in HCC and showed diagnostic performance for differentiating HCC from healthy controls, CHB, and cirrhosis; it was included in a 3-circRNA panel with high accuracy for early HCC detection and surveillance.
Description:

circ_0075792 is a urinary circRNA biomarker that is significantly up-regulated in HBV-related HCC compared with healthy controls, CHB patients, and HBV-induced cirrhosis patients. It was incorporated into a three-circRNA logistic regression panel for noninvasive HCC detection, especially early HCC.
Confidence score:

0.4187
Other information
Title:

Urinary Circular RNA Panels to Detect HBV-Related Hepatocellular Carcinoma: A Multicenter, Large-Scale, Case-Control Study.

Journal: Journal of the National Comprehensive Cancer Network : JNCCN
Published: 2024
PubMed ID: 39729708
Study type:

clinical study
Data availability: Supplementary material associated with this article is available online at https://doi.org/10.6004/jnccn.2024.7058
Code availability: -