| Expression pattern: |
UP |
| Associated gene: |
HOXA9 |
| Associated microRNA: |
miR-1297 |
| Biological function: |
Circ_DOCK1 promotes OSCC cell proliferation, colony formation, migration, invasion, glycolysis and tumor growth in vivo; circ_DOCK1 knockdown suppresses these malignant activities. |
| Molecular mechanism: |
circ_DOCK1 acts as a miR-1297 sponge and positively regulates HOXA9 expression, forming the circ_DOCK1-miR-1297-HOXA9 regulatory network. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Actinomycin D / DRB Stability Assay; RNase R Treatment; Transfection; EdU Staining; Colony Formation Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_DOCK1 expression was associated with advanced stage, bigger tumor size, lymph node metastasis and relatively poor survival of OSCC patients; circ_DOCK1 may provide promising biomarkers for diagnosis and treatment of OSCC. |
| Description: |
circ_DOCK1 is up-regulated in OSCC tumor tissues and cell lines, and high expression is associated with advanced disease features and poor survival. Functionally, circ_DOCK1 promotes OSCC proliferation, colony formation, migration, invasion, glycolysis and in vivo tumor growth. Mechanistically, it acts as a miR-1297 sponge to increase HOXA9 expression through the circ_DOCK1-miR-1297-HOXA9 regulatory network. |
| Confidence score: |
0.8568 |