| Expression pattern: |
UP |
| Associated gene: |
PROM2, AGO2, GPX4, SLC7A11, E-cadherin, N-cadherin |
| Associated microRNA: |
miR-608 |
| Biological function: |
Promotes proliferation, migration, and invasion of endometriosis cells and inhibits ferroptosis, thereby promoting EM progression. |
| Molecular mechanism: |
circ_0008927 functions as a ceRNA sponge for miR-608, upregulates PROM2, and inhibits ferroptosis in EM cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ferroptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; RNA-seq; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Flow Cytometry（Non-apoptosis/cycle）; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ_0008927 may serve as a potential therapeutic target for EM. |
| Description: |
circ_0008927 is up-regulated in endometriosis tissues and hEM15A cells. It promotes proliferation, migration, and invasion while inhibiting ferroptosis through a ceRNA mechanism involving miR-608 and PROM2, suggesting a potential therapeutic relevance in EM. |
| Confidence score: |
0.8341 |