| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Exosomal circ670 promotes tobacco smoke-induced gastric cancer development by enhancing the stemness, spheroidizing ability, EMT process, migration, and invasion of gastric cancer stem cells; circ670 knockdown inhibits stemness and EMT, whereas circ670 overexpression promotes them. |
| Molecular mechanism: |
Exosome-mediated transport of circ670 from tobacco smoke-treated gastric cancer stem cells promotes stemness and EMT in GCSCs. |
| Biological pathway or process: |
stemness (promotes); EMT (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; RNase R Treatment; Transfection; Western Blot; Transwell Assay |
| Clinical significance: |
circ670 was highly expressed in gastric cancer tissues from patients with smoking history and may be a potential prevention and treatment target for gastric cancer. |
| Description: |
This study identified circ670 as an up-regulated exosomal circRNA in gastric cancer tissues from patients with smoking history, tobacco smoke-induced GCSCs, and GCSC-derived exosomes. Exosomal circ670 promotes tobacco smoke-triggered gastric cancer development by enhancing GCSC stemness and EMT, and its knockdown suppresses these effects while overexpression enhances them. The authors propose exosomal circ670 as a potential prevention and treatment target for gastric cancer. |
| Confidence score: |
0.6676 |