circRNA basic information
circBase ID: -
Name: mmu_circ_Nrip1
Synonym: mmu_circRNA_001155
Host Gene: Nrip1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005292
MONDO name: colitis
Disease details: colitis
Disease DO ID:
 0060180
Disease MeSH ID:
 D003092
Disease NCIt ID:
 C26723
Disease ICD11 ID:
 1870792958
Disease OMIM ID:
 -
Species: Mouse
Species details: Mus musculus
Tissue specimen:

AOM/DSS mouse colonic tumor tissue; normal colonic tissue; colon tissues
Cell lines:

-
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: May be involved in the development of colitis-induced colon carcinoma; no direct phenotypic function was experimentally tested.
Molecular mechanism: Predicted miRNA sponge-related circRNA-miRNA-mRNA mechanism.
Biological pathway or process:

ceRNA regulation (other); MAPK (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNase R Treatment; circRNA-seq; RT-qPCR; Bioinformatics Analysis; In Vivo Animal Model; H&E Staining
Clinical significance:

Potential biomarker or therapeutic target for colitis-associated colorectal carcinogenesis.
Description:

mmu_circRNA_001155, derived from Nrip1, was up-regulated in AOM/DSS mouse colonic tumor tissue. The article links its dysregulation to predicted circRNA-miRNA-mRNA networks and possible involvement in colitis-induced colon carcinoma.
Confidence score:

0.5802
Other information
Title:

Comprehensive analysis of differential circular RNA expression in a mouse model of colitis-induced colon carcinoma.

Journal: Molecular carcinogenesis
Published: 2018
PubMed ID: 30182433
Study type:

combined biological and bioinformatics study
Data availability: -
Code availability: -