| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Circ_0071662 was evaluated as a diagnostic and prognostic biomarker for HCC; decreased expression was associated with poor survival, tumor metastasis, vascular invasion, tumor size, and development of radioresistance after SBRT. |
| Molecular mechanism: |
No molecular mechanism was experimentally investigated in HCC; the study focused on expression, diagnostic/prognostic value, and association with radioresistance. |
| Biological pathway or process: |
radioresistance (other); metastasis (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Cohort Study; Survival Analysis |
| Clinical significance: |
Circ_0071662 may serve as a potential biomarker to improve HCC diagnosis and prognosis; decreased plasma expression separated HCC patients from healthy controls and other patient groups, was associated with poor survival, and may indicate development of radioresistance. |
| Description: |
Circ_0071662 is downregulated in HCC plasma and tumor tissues. Its decreased expression can distinguish HCC from healthy controls and other clinically similar diseases, is associated with poor survival and adverse clinical features, and may indicate radioresistance after SBRT. |
| Confidence score: |
0.4992 |