| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-1238, miR-1247e5p, miR-1247-5p |
| Biological function: |
Promotes CSCC cell proliferation, colony formation, migration and invasion, and suppresses apoptosis; associated with tumor aggressiveness. |
| Molecular mechanism: |
circ_0070934 functions as an oncogenic circRNA by sponging and inhibiting miR-1238 and miR-1247e5p. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
Higher expression of circ_0070934 associates with tumor aggressiveness and may offer a potential therapeutic target for CSCC. |
| Description: |
circ_0070934 is up-regulated in CSCC tissues and cell lines. It acts as an oncogenic circRNA that promotes proliferation, colony formation, migration and invasion while inhibiting apoptosis, at least partly by sponging and suppressing miR-1238 and miR-1247e5p. Higher circ_0070934 expression is associated with tumor aggressiveness and may represent a therapeutic target for CSCC. |
| Confidence score: |
0.6521 |