| Expression pattern: |
UP |
| Associated gene: |
IGFBP5 |
| Associated microRNA: |
miR-661 |
| Biological function: |
circPIP5K1A promotes ovarian cancer cell proliferation, migration, invasion, and tumor growth; circPIP5K1A knockdown suppresses these malignant phenotypes. |
| Molecular mechanism: |
circPIP5K1A acts as a ceRNA/miRNA sponge for miR-661, thereby regulating IGFBP5 expression through the miR-661/IGFBP5 axis. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circPIP5K1A expression predicts poor prognosis in ovarian cancer patients and may serve as a candidate prognostic marker and therapeutic target. |
| Description: |
circPIP5K1A is up-regulated in ovarian cancer tissues and cell lines, and high expression is associated with poor prognosis. Functionally, circPIP5K1A promotes ovarian cancer proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it acts as a ceRNA for miR-661 to regulate IGFBP5 expression through the circPIP5K1A/miR-661/IGFBP5 axis. |
| Confidence score: |
0.7373 |