| Expression pattern: |
DN |
| Associated gene: |
ATXN1 |
| Associated microRNA: |
miR-1290, miR-136-5P, miR-382-5P |
| Biological function: |
May act as a tumor suppressor in OSCC and modulate miR-136-5P/miR-382-5P to increase ATXN1 expression in OSCC cell lines. |
| Molecular mechanism: |
Predicted to act as a miRNA sponge (ceRNA) for miR-136-5P and miR-382-5P, thereby increasing ATXN1 expression. |
| Biological pathway or process: |
ceRNA regulation (other); Notch (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Western Blot; ROC Analysis |
| Clinical significance: |
May serve as a potential biomarker for the diagnosis of OSCC; ROC AUC=0.7642; expression associated with pathological differentiation. |
| Description: |
hsa_circ_0008309 is down-regulated in OSCC tissues and is associated with pathological differentiation, showing potential diagnostic value. Mechanistically, it is predicted and functionally supported to repress miR-136-5P/miR-382-5P and increase ATXN1 expression, consistent with a ceRNA-like role in OSCC cell lines. |
| Confidence score: |
0.7039 |