circRNA basic information
circBase ID: hsa_circ_0136959
Name: hsa_circ_CSPP1
Synonym: circular RNA CSPP1
Host Gene: CSPP1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer / CC
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

human cervical cancer tissues; adjacent tissues; cervical squamous cell carcinoma tissues; paired paracancerous cervical tissues; tumor tissues
Cell lines:

HeLa; Caski; SiHa; HT-3; C33A; HaCaT
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: ITGB1, ITGB1 mRNA, PI3K, Akt
Associated microRNA: miR-361-5p
Biological function: Promotes cervical cancer cell proliferation, migration, and tumor growth; inhibits apoptosis.
Molecular mechanism: hsa_circ_CSPP1 acts through a miR-361-5p/ITGB1 axis and modulates the PI3K-Akt signaling pathway.
Biological pathway or process:

PI3K/AKT (promotes); proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes); other pathway/process (promotes)
Detected method:
Q
M
Validation methods:

RT-qPCR; Microarray; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

hsa_circ_CSPP1 is upregulated in cervical cancer clinical tissues and may be a promising biomarker of cervical tumors.
Description:

hsa_circ_CSPP1 is upregulated in cervical cancer tissues and cell lines. It promotes cervical cancer proliferation, migration, and xenograft tumor growth while inhibiting apoptosis, at least partly by sponging miR-361-5p to regulate ITGB1 and activate the PI3K-Akt pathway.
Confidence score:

0.6829
Other information
Title:

Hsa_circ_CSPP1/MiR-361-5p/ITGB1 Regulates Proliferation and Migration of Cervical Cancer (CC) by Modulating the PI3K-Akt Signaling Pathway.

Journal: Reproductive sciences (Thousand Oaks, Calif.)
Published: 2020
PubMed ID: 32046405
Study type:

combined biological and clinical study; bioinformatics study
Data availability: GSE9750; GSE102686; GEO database
Code availability: -