| Expression pattern: |
UP |
| Associated gene: |
STAT3 |
| Associated microRNA: |
miR-337-3p, hsa-miR-502-5p |
| Biological function: |
promotes gastric cancer cell proliferation and invasion |
| Molecular mechanism: |
acts as a miR-337-3p sponge to upregulate STAT3 (ceRNA mechanism) |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot |
| Clinical significance: |
hsa_circ_0000117 expression was positively correlated with advanced TNM stage and lymphatic metastasis in GC patients |
| Description: |
hsa_circ_0000117 is up-regulated in gastric cancer tissues/cell lines and promotes proliferation and invasion. Mechanistically, it localizes to the cytoplasm and functions as a ceRNA sponge for miR-337-3p, thereby relieving repression of STAT3 and driving GC progression. |
| Confidence score: |
0.7283 |