| Expression pattern: |
UP |
| Associated gene: |
SNRPA |
| Associated microRNA: |
miR-361-3p |
| Biological function: |
Promotes GC cell proliferation, migration, invasion, glycolysis, tumorigenesis and metastasis, and inhibits apoptosis. |
| Molecular mechanism: |
circ_0009910 acts as a miR-361-3p sponge and positively regulates SNRPA expression through the miR-361-3p/SNRPA axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circ_0009910 might be a target for GC treatment. |
| Description: |
circ_0009910 is up-regulated in gastric cancer tissues and cell lines. It promotes proliferation, migration, invasion, glycolysis, metastasis-related phenotypes and in vivo tumor growth while suppressing apoptosis. Mechanistically, circ_0009910 sponges miR-361-3p to positively regulate SNRPA, suggesting that targeted inhibition of circ_0009910 may be therapeutically relevant in GC. |
| Confidence score: |
0.8295 |