| Expression pattern: |
DN |
| Associated gene: |
METTL3 |
| Associated microRNA: |
- |
| Biological function: |
hsa_circ_0136959 acts as a tumor suppressor in PTC by suppressing proliferation, migration, and invasion and accelerating ferroptosis of PTC cells. |
| Molecular mechanism: |
METTL3-mediated m6A modification enhances hsa_circ_0136959 expression, which subsequently restricts PTC tumor characteristics by accelerating ferroptosis. |
| Biological pathway or process: |
ferroptosis (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits); m6A modification (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; MeRIP / MeRIP-seq; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Flow Cytometry（Non-apoptosis/cycle）; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0136959 may represent a viable therapeutic target through its regulation of ferroptosis in PTC; the study also implies potential prognostic significance. |
| Description: |
hsa_circ_0136959 is downregulated in papillary thyroid cancer tissues and cell lines. Its overexpression suppresses PTC cell proliferation, migration, and invasion and promotes ferroptosis. METTL3 increases hsa_circ_0136959 expression through m6A modification, supporting a tumor-suppressive METTL3/hsa_circ_0136959/ferroptosis mechanism. |
| Confidence score: |
0.7519 |