| Expression pattern: |
UP |
| Associated gene: |
PLA2G4E |
| Associated microRNA: |
- |
| Biological function: |
Promotes HUVEC proliferation, migration, and tube formation (angiogenesis) in the post-RFA (heat-stimulated) context of HCC via exosomes. |
| Molecular mechanism: |
Exosomal circPTPRK upregulates PLA2G4E in recipient HUVECs; PLA2G4E overexpression rescues the inhibitory effects caused by circPTPRK knockdown. |
| Biological pathway or process: |
angiogenesis (promotes); proliferation (promotes); migration (promotes); VEGF/VEGFR (other); TGF-beta/SMAD (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Sanger Sequencing; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Tube Formation Assay; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circPTPRK is up-regulated in heat-stimulated HCC cell-derived exosomes and increases in HUVECs after exosome uptake. Exosomal circPTPRK promotes HUVEC proliferation, migration, and tube formation, at least partly by upregulating the downstream target PLA2G4E. |
| Confidence score: |
0.5979 |