circRNA basic information
circBase ID: hsa_circ_0048677
Name: hsa_circ_UHRF1
Synonym: cir-cUHRF1
Host Gene: UHRF1
Genomic location(hg19): chr19:4941539-4945977:+
Genomic location(hg38): chr19:4941527-4945965:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: Identified as a differentially expressed serum exosomal circRNA candidate in NSCLC array screening; no NSCLC-specific biological function was experimentally validated.
Molecular mechanism: No NSCLC-specific molecular mechanism was experimentally defined for this circRNA in this study.
Biological pathway or process:

not specified
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

Potential value as a diagnostic biomarker candidate in NSCLC based on differential serum exosomal circRNA screening, but not clinically validated by qRT-PCR in NSCLC patient cohorts in this study.
Description:

hsa_circ_0048677 was selected as one of five serum exosomal circRNAs of interest through circRNA array screening and literature intersection. In this study, it was not carried forward for NSCLC patient-cohort qRT-PCR validation, so its NSCLC association is supported only by screening-level evidence.
Confidence score:

0.1768
Other information
Title:

Serum exosomal hsa_circ_0069313 has a potential to diagnose more aggressive non-small cell lung cancer.

Journal: Clinical biochemistry
Published: 2022
PubMed ID: 35077682
Study type:

combined clinical and bioinformatics study
Data availability: Supplementary data to this article can be found online at https://doi. org/10.1016/j.clinbiochem.2022.01.005.
Code availability: -