| Expression pattern: |
UP |
| Associated gene: |
HMGN5 |
| Associated microRNA: |
miR-450b-3p |
| Biological function: |
Promotes proliferation, invasion, and migration of NSCLC cells. |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-450b-3p to increase HMGN5 mRNA/protein expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Western Blot; CCK8; Wound Healing Assay; Transwell Assay |
| Clinical significance: |
CircTADA2A expression was correlated with poor overall survival of NSCLC patients. |
| Description: |
circTADA2A is up-regulated in NSCLC tissues and cell lines and its high expression is associated with poorer overall survival. Functionally, circTADA2A promotes NSCLC cell proliferation, migration and invasion by acting as a ceRNA that sponges miR-450b-3p and thereby upregulates HMGN5 expression. |
| Confidence score: |
0.7113 |