circRNA basic information
circBase ID: hsa_circ_0001380
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr3:196118683-196129890:-
Genomic location(hg38): chr3:196391812-196403019:-
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood exosomes; tissue samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: SMARCA2
Associated microRNA: hsa-miR-29a-3p, hsa-miR-124-3p, hsa-miR-126-3p, hsa-miR-107, hsa-miR-15a-5p, hsa-miR-29a-5p, hsa-miR-211-5p, hsa-miR-3619-5p, hsa-miR-30c-5p, hsa-miR-9-5p, hsa-miR-373-3p, hsa-miR-106b-5p, hsa-miR-17-5p, hsa-miR-452-5p, hsa-miR-218-5p, hsa-miR-34c-3p, hsa-miR-34a-5p, hsa-miR-449a, hsa-let-7i-3p, hsa-miR-186-5p, hsa-miR-199a-5p, hsa-miR-199a-3p, hsa-miR-18a-5p, hsa-miR-655-3p
Biological function: potential regulatory role in HCC pathogenesis via extensive interactions with miRNAs and RNA regulatory network
Molecular mechanism: predicted physical interactions with multiple miRNAs in an RNA regulatory network, potentially involving competitive binding or co-regulation mechanisms
Biological pathway or process:

ceRNA regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

confirmed differential expression; potential biomarker/therapeutic target in liver cancer
Description:

This study identified hsa_circ_0001380 as a differentially expressed exosomal circRNA in hepatocellular carcinoma. It was predicted to physically interact with 23 of 24 analyzed miRNAs (all except hsa-miR-30c-5p), suggesting a potential role in post-transcriptional regulation through a miRNA-centered regulatory network. The circRNA was proposed as a candidate biomarker and potential therapeutic target for liver cancer.
Confidence score:

0.1768
Other information
Title:

Integrative analysis of exosomal ncRNAs and their regulatory networks in liver cancer progression.

Journal: Practical laboratory medicine
Published: 2025
PubMed ID: 40226122
Study type:

bioinformatics study
Data availability: GSE100206; GSE100207
Code availability: -