circRNA basic information
circBase ID: hsa_circ_0006156
Name: hsa_circ_FNDC3B
Synonym: circFNDC3B
Host Gene: FNDC3B
Genomic location(hg19): chr3:171965322-171969331:+
Genomic location(hg38): chr3:172247532-172251541:+
Subcellular localization: nucleus and cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018708
MONDO name: squamous cell carcinoma of the oral tongue
Disease details: oral tongue squamous cell carcinoma / OTSCC
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 C8169
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

human OTSCC tissues; paracancerous noncancerous tissues
Cell lines:

SCC9; SCC15; CAL27; SCC25; HOK; HEK-293 T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: MED1
Associated microRNA: miR-1322
Biological function: promotes OTSCC cell proliferation, migration, invasion, tumor growth, and disease progression
Molecular mechanism: circFNDC3B functions through a ceRNA mechanism by sponging miR-1322 and promoting MED1 expression
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes)
Detected method:
Q
H
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; FISH / smFISH; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; Colony Formation Assay; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; Western Blot; Bioinformatics Analysis
Clinical significance:

circFNDC3B may be a potential therapeutic target for OTSCC
Description:

circFNDC3B is up-regulated in OTSCC tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, and xenograft tumor growth through the circFNDC3B/miR-1322/MED1 regulatory axis, suggesting potential therapeutic relevance in OTSCC.
Confidence score:

0.7795
Other information
Title:

Overexpression of circFNDC3B promotes the progression of oral tongue squamous cell carcinoma through the miR-1322/MED1 axis.

Journal: Head & neck
Published: 2022
PubMed ID: 35916453
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -