| Expression pattern: |
UP |
| Associated gene: |
MUC19 |
| Associated microRNA: |
miR-1287-5p |
| Biological function: |
promotes glycolysis, cell viability/proliferation, migration, invasion, and xenograft tumor growth in breast cancer under hypoxia |
| Molecular mechanism: |
circ_0001982 functions as a ceRNA sponge for miR-1287-5p to upregulate MUC19 expression, thereby promoting malignant phenotypes under hypoxia |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
circ_0001982 expression was associated with tumor size, TNM stages, and lymphatic metastasis in breast cancer patients |
| Description: |
In breast cancer, circ_0001982 is up-regulated (including under hypoxia) and mainly localized in the cytoplasm. It promotes glycolysis and malignant behaviors (viability/proliferation, migration, invasion) by acting as a ceRNA sponge for miR-1287-5p, thereby increasing MUC19 expression, and its knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.7283 |