| Expression pattern: |
UP |
| Associated gene: |
S100A14 |
| Associated microRNA: |
miR-128-3p |
| Biological function: |
promotes CC cell proliferation, migration, invasion, EMT progression, tumor growth, and malignant behaviors |
| Molecular mechanism: |
circ_0007142 acts as a miR-128-3p sponge to upregulate S100A14 expression and promote CC progression via the miR-128-3p/S100A14 axis |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis |
| Clinical significance: |
high circ_0007142 level was associated with shorter overall survival and might be used as a prognostic indicator |
| Description: |
circ_0007142 is up-regulated in cervical cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, EMT progression, and xenograft tumor growth by sponging miR-128-3p to increase S100A14 expression. High circ_0007142 expression is associated with shorter overall survival in CC patients, suggesting prognostic and therapeutic relevance. |
| Confidence score: |
0.8595 |