circRNA basic information
circBase ID: hsa_circ_0008717
Name: hsa_circ_ABCB10
Synonym: -
Host Gene: ABCB10
Genomic location(hg19): chr1:229665945-229678118:-
Genomic location(hg38): chr1:229530198-229542371:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: nonsmall cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues
Cell lines:

A549; PC9; H1299; H1975; H1650; BEAS-2B; HEK293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: FOXR2
Associated microRNA: miR-1252
Biological function: promotes NSCLC cell proliferation and migration and promotes tumor growth in vivo
Molecular mechanism: ceRNA sponging of miR-1252 to increase FOXR2 expression
Biological pathway or process:

proliferation (promotes); migration (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; In Vivo Animal Model; Western Blot
Clinical significance:

-
Description:

circABCB10 (hsa_circ_0008717) is up-regulated in NSCLC cell lines and promotes proliferation, migration, and xenograft tumor growth. Mechanistically, it acts as a miR-1252 sponge to relieve repression of FOXR2, forming a circABCB10/miR-1252/FOXR2 ceRNA axis.
Confidence score:

0.5607
Other information
Title:

CircABCB10 promotes nonsmall cell lung cancer cell proliferation and migration by regulating the miR-1252/FOXR2 axis.

Journal: Journal of cellular biochemistry
Published: 2019
PubMed ID: 30417418
Study type:

biological research
Data availability: -
Code availability: -