| Expression pattern: |
UP |
| Associated gene: |
CDCA3, Ago2, Bax, Bcl-2, Ki67 |
| Associated microRNA: |
miR-520a-3p |
| Biological function: |
Promotes breast cancer cell growth, viability, proliferation, motility, invasiveness, metastasis-related phenotypes and xenograft tumorigenicity, while inhibiting apoptosis. |
| Molecular mechanism: |
circ_0038632 functions as a ceRNA/miRNA sponge for miR-520a-3p and post-transcriptionally modulates CDCA3 expression through the miR-520a-3p/CDCA3 cascade. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0038632 may be a potential target for BC treatment; previous studies reported that circ_0038632 is related to poor survival of BC patients. |
| Description: |
circ_0038632 is up-regulated in breast cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes BC cell proliferation, migration, invasion, and xenograft tumor growth while suppressing apoptosis by sponging miR-520a-3p and increasing CDCA3 expression. The study suggests circ_0038632 as a potential therapeutic target for breast cancer. |
| Confidence score: |
0.8006 |