circRNA basic information
circBase ID: hsa_circ_0008887
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): chr11:33307958-33350179:+
Genomic location(hg38): chr11:33286412-33328633:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0100096
MONDO name: COVID-19
Disease details: COVID-19
Disease DO ID:
 0080600
Disease MeSH ID:
 D000086382
Disease NCIt ID:
 -
Disease ICD11 ID:
 1730556128
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells; peripheral venous blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Upregulated in PBMCs of COVID-19 patients and proposed as a potential diagnostic biomarker for COVID-19; may be involved in immune response to viral infection.
Molecular mechanism: No functional or mechanistic validation was performed in this study; the circRNA-disease association was based on expression and ROC analyses.
Biological pathway or process:

immune regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Potential biomarker for COVID-19 diagnosis; ROC analysis showed AUC 0.717 with sensitivity 83% and specificity 55%.
Description:

circHIPK3/circRNA100783 was significantly upregulated in PBMCs from COVID-19 patients compared with healthy controls. The study suggests it may participate in immune responses to viral infection and may serve as a COVID-19 diagnostic biomarker, although no functional mechanism was experimentally tested.
Confidence score:

0.4187
Other information
Title:

Immune Regulatory Circular RNAs, circRasGEF1B and circHIPK3, are Upregulated in Peripheral Blood Mononuclear Cells of COVID-19 Patients.

Journal: Genetic testing and molecular biomarkers
Published: 2024
PubMed ID: 39503793
Study type:

clinical study
Data availability: All data will be available from the corresponding author, upon reasonable request.
Code availability: -