| Expression pattern: |
UP |
| Associated gene: |
ATF7IP |
| Associated microRNA: |
hsa-miR-107, hsa-miR-214-3p |
| Biological function: |
promotes extramural venous invasion (EMVI) and invasion; promotes proliferation; inhibits apoptosis |
| Molecular mechanism: |
May act as a miRNA sponge for hsa-miR-107 and hsa-miR-214-3p; downstream targets predicted (overlapping target mRNAs) including ATF family genes. |
| Biological pathway or process: |
invasion (promotes); proliferation (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Bioinformatics Analysis; Transfection; Annexin V/PI Flow Cytometry; Transwell Assay; CCK8; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
hsa_circ_0097977 may serve as a promising therapeutic target and biomarker for GC particularly in patients with EMVI. |
| Description: |
hsa_circ_0097977 is up-regulated in EMVI-positive gastric cancer samples and is functionally pro-tumorigenic. Its knockdown reduces EMVI and cell invasion while increasing apoptosis, and bioinformatics suggests a ceRNA mechanism involving hsa-miR-107/hsa-miR-214-3p and predicted downstream mRNA targets. |
| Confidence score: |
0.5089 |