circRNA basic information
circBase ID: -
Name: hsa_circ_SMG1
Synonym: hsa_circRNA_038288
Host Gene: SMG1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005147
MONDO name: type 1 diabetes mellitus
Disease details: fulminant type 1 diabetes
Disease DO ID:
 9744
Disease MeSH ID:
 D003922
Disease NCIt ID:
 C2986
Disease ICD11 ID:
 1651053999
Disease OMIM ID:
 222100
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells / PBMCs; peripheral blood samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PTEN, EEA1, SLC25A36, LNPEP, PSD3, JAG1, MCL1, API5, PPARGC1B, CCND2, KLF4, MACF1, CALD1, FN1, NFAT5
Associated microRNA: hsa-miR-298, hsa-miR-320a, hsa-miR-375, hsa-miR-449a, hsa-miR-137
Biological function: Potentially involved in immune regulation and diabetes-related progression of FT1D and T1D; may act as a competing endogenous RNA and may have coding potential.
Molecular mechanism: Predicted ceRNA mechanism through circRNA-miRNA-mRNA signalling pathways; predicted coding potential via IRESs, ORFs, and methylation modification sites.
Biological pathway or process:

immune regulation (other); ceRNA regulation (other); other pathway/process (other); m6A modification (other); mRNA stability (other)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential tool for differentiating and diagnosing FT1D.
Description:

hsa_circRNA_038288 was down-regulated in PBMCs from FT1D patients compared with T1D patients and was validated by RT-qPCR. The study predicts that it participates in diabetes- and immune regulation-related circRNA-miRNA-mRNA networks, especially a possible hsa_circRNA_038288-hsa-miR-320a-NFAT5 axis, and may also have protein-coding potential.
Confidence score:

0.5135
Other information
Title:

Differences in Immune Cell-Derived Circular RNA Between Fulminant Type 1 Diabetes and Type 1 Diabetes.

Journal: Diabetes/metabolism research and reviews
Published: 2024
PubMed ID: 39497470
Study type:

combined biological and clinical study
Data availability: supplemental material files
Code availability: -