| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-9-5p |
| Biological function: |
Promotes GC cell proliferation, migration, invasion, metastasis and malignant progression; acts as a prognostic biomarker and tumor promoter. |
| Molecular mechanism: |
hsa_circ_0008667 negatively regulates miR-9-5p; miR-9-5p inhibition reverses the suppression of GC cell proliferation, migration and invasion caused by hsa_circ_0008667 knockdown. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High hsa_circ_0008667 expression is associated with lymph node metastasis, advanced TNM stage, poorer survival, and is an independent prognostic indicator for GC. |
| Description: |
hsa_circ_0008667 is up-regulated in gastric cancer tissues and cells and its high expression is associated with lymph node metastasis, advanced TNM stage, and poor survival. Functionally, hsa_circ_0008667 promotes GC cell proliferation, migration, invasion, and metastasis, mainly through negative regulation of miR-9-5p. The study supports hsa_circ_0008667 as a prognostic biomarker and potential therapeutic target for GC. |
| Confidence score: |
0.7752 |